ISOLATION AND CHARACTERIZATION OF A NEW ANTIBIOTIC, NEOPLURAMYCIN

Abstract

A new crystalline antibiotic named neopluramycin, which inhibits growth of Gram-positive bacteria, leukemia L-1210 in mice and Yoshida rat sarcoma cells in tissue culture, has been isolated from the cultured broth of a strain of Streptomyces pluricolorescens. It was obtained as orange crystals, and analytical data and molecular weight determination are consistent with the empirical formula C40H50N20O10. Neopluramycin resembles pluramycin A, but is differentiated by its antibacterial spectrum, toxicity, thin-layer chromatography, and infrared absorption spectrum.