Antimicrobial Agents and Chemotherapy · 1974 · 38 citations · 11 references
PharmacyMedicinal ChemistryMicrobiologyAntimicrobial PharmacologyDrug DiscoveryStructure-activity RelationshipsAntibacterial PharmacologyRibosome FunctionAntibiotic Binding Sites On The RibosomeAntibiotic Inhibition Of TranslationAntibiotic Mechanisms Of ActionBacterial Ribosome FunctionLigand DissociationMacrolide AntibioticsRibosomal Rna-protein Interactions
We examined the effect of leucomycins, leucomycin derivatives, and other 16-membered macrolides (tylosin, niddamycin, spiramycin I, and spiramycin III) on [(14)C]erythromycin binding to ribosomes. Results of these studies enabled determination of the association and dissociation constants for the binding of each of these compounds to Escherichia coli ribosomes. In addition, the binding of the leucomycins and the leucomycin derivatives to ribosomes in general correlated with their antimicrobial activity.
11