Small · 2010 · 60 citations · 42 references
MedicineMolecular BiologyOncologyBiosensorsMolecular DiagnosticsProteomicsCancer BiomarkersCancer Molecular DiagnosticsNanoparticle-based ImmunotechnologyProstate-specific Antigen TestingTumor AntigensTumor MarkersCancer Biomarker DetectionNanoparticle-based ImmunoassaysNanoparticle-based ProbesProstate Tumor MarkersProtein DetectionRolling Circle AmplificationTumor Marker Assay DevelopmentUltrasensitive Detection
An on-nanoparticle rolling-circle amplification (nanoRCA) strategy allows the visual detection of 30 molecules of carcinoembryonic antigen with at least 1010-fold selectivity over a range of noncognate proteins. The nanoRCA assay is applicable to the detection of two tumor markers in biological fluids: prostate-specific antigen in spiked sera and interleukin-8 in saliva. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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In vitro selection of RNA molecules that bind specific ligands
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In vivo cancer targeting and imaging with semiconductor quantum dots
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