Synthesis of a β-diketone from a dithioacetal. A model study for the synthesis of an ionomycin fragment

Abstract

The anions of dithioacetals react with epoxides to give β-hydroxydithioketals, which can be oxidized and hydrolyzed to β-diketones. This sequence is applied to a model study of the synthesis of the C-5 to C-15 fragment of the antibiotic ionomycin.