2-Methoxyestradiol at low dose induces differentiation of myeloma cells

Plasma cell differentiation requires the transcription factor XBP-1

Andreas Reimold, Neal N. Iwakoshi, John Manis et al. · Nature · 2001 · 1.3K citations

Transcriptional Regulation, Developmental Biology, Cell Regulation +6

Superoxide dismutase as a target for the selective killing of cancer cells

Peng Huang, Feng Li, Eli Oldham et al. · Nature · 2000 · 837 citations

Tumor Biology, Selective Killing, Medicine +11

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells.

Guoqiang Chen, Xuegeng Shi, Wei Tang et al. · PubMed · 1997 · 802 citations

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

Theodore Fotsis, Youming Zhang, Michael S. Pepper et al. · Nature · 1994 · 741 citations

Tumor Biology, Angiogenesis, Tumour Growth +11

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

Nancy Klauber, Sareh Parangi, Evelyn Flynn et al. · PubMed · 1997 · 527 citations

Breast Oncology, Chemoprevention Strategy, Tumor Biology +17