The Open Nitric Oxide Journal · 2010 · 26 citations · 139 references
Life SciencesBiochemistryPharmacologyEnzymologyMetabolismMolecular PharmacologyAmino Acid MetabolismG Protein-coupled Receptor SignalingNeurotransmitter MetabolismArginine MetabolismG-protein-coupled ReceptorsNitric OxideNitric Oxide MetabolismNitric Oxide ProductionNitric Oxide SignalingNitric Oxide Synthase Regulation
The present review will give an overview of the biochemistry and metabolism of L-arginine focusing on the mechanisms which may either provide or limit cellular availability of this amino acid for nitric oxide synthases and arginase / polyamine pathway and describe possible interactions between these pathways. In addition, emerging species differences in the expression and role of arginases are addressed, as they may have considerable impact on the translation of results from animal models into human. In addition, the recently described G-protein-coupled receptor GPRC6A receptors as target for L-arginine and drugs modulating the activity of arginases and nitric oxide synthases are discussed.
139
Vascular endothelial cells synthesize nitric oxide from L-arginine
Richard Palmer, D. Ashton, Salvador Moncada · Nature · 1988 · 4.8K citations