A PET study with [¹¹C]AZ10419369 to determine brain 5-HT_1Breceptor occupancy of zolmitriptan in healthy male volunteers

Abstract

This is the first demonstration of CNS 5-HT1B receptor occupancy of a triptan. The findings are consistent with the low receptor occupancy previously reported in PET studies with agonists at other G protein coupled receptors.