Journal of Virology · 2013 · 34 citations · 56 references
Life SciencesBiologyMolecular BiologyMembrane TraffickingMolecular VirologyVirologyOncogenic VirusesPhosphoinositide SignalingProtein TargetingViral EntryViral InfectionsVirus-host InteractionsNuclear Membrane TraffickingPhosphoinositide-binding DomainsTargetingViral Envelope GlycoproteinsViral Envelope ProteinsVirus-host Membrane InteractionsVirus-like Particle AssemblyVirus-like Particle Self-assembly
Retroviral Gag proteins direct virus particle assembly from the plasma membrane (PM). Phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] plays a role in PM targeting of several retroviral Gag proteins. Here we report that depletion of intracellular PI(4,5)P(2) and phosphatidylinositol-(3,4,5)-triphosphate [PI(3,4,5)P(3)] levels impaired Rous sarcoma virus (RSV) Gag PM localization. Gag mutants deficient in nuclear trafficking were less sensitive to reduction of intracellular PI(4,5)P(2) and PI(3,4,5)P(3), suggesting a possible connection between Gag nuclear trafficking and phosphoinositide-dependent PM targeting.
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NIH Image to ImageJ: 25 years of image analysis
Caroline A Schneider, Wayne Rasband, Kevin W. Eliceiri · Nature Methods · 2012 · 65.2K citations
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