Publication | Closed Access
Catalytic mechanism of C–F bond cleavage: insights from QM/MM analysis of fluoroacetate dehalogenase
80
Citations
29
References
2015
Year
BiosynthesisFluoroacetate DehalogenaseEngineeringBiochemistryNatural SciencesBiocatalysisEnzyme CatalysisMolecular BiologyC–f Bond CleavageFluorous SynthesisOrganic ChemistryStructure-function Enzyme KineticsCatalytic MechanismsCatalytic Mechanism
The catalytic mechanisms of fluoroacetate dehalogenase (FAcD) toward substrates fluoroacetate and chloroacetate were studied by a combined quantum mechanics/molecular mechanics (QM/MM) method.
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