Antioxidative effect of melatonin, ascorbic acid and<i>N</i>-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats

Abstract

Oxidative injury plays an important role not only in the pathogenesis of AP but also in pancreatitis-induced hepatic damage. Antioxidant agents such as melatonin and ascorbic acid + N-acetyl cysteine, are capable of limiting pancreatic and hepatic damage produced during AP via restoring tissue antioxidant enzyme activities.