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The structures of cytochalasins A and B
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1967
Year
Crystal StructureNatural Product SynthesisBiochemistryNupheus AlkaloidsMedicineNatural SciencesAntiparasitic AgentMolecular BiologySecondary MetaboliteStructure ElucidationCytochalasins ACellular StructurePharmacologyCrystallographyStructural BiologyDrug DiscoveryCytochalasin B
The structures of cytochalasins A and B, metabolites of Helminthosporium dematioideum showing novel effects on mammalian cells, have been determined. Cytochalasin B is identical with phomin. (–)-α-Methyladipic acid is shown to have the R-configuration contrary to a previous assignment; the absolute configurations of the Nupheus alkaloids therefore require revision.