Concepedia

Assessment of immune response to repeat stimulation with BCG vaccine using in vitro PBMC model

Rajpal S. Kashyap, Aliabbas A. Husain, Shweta H. Morey, Milind S. Panchbhai, Poonam S. Deshpande, Hemant J. Purohit, Girdhar M. Taori, Hatim F. Daginawala

Journal of Immune Based Therapies and Vaccines · 2010 · 18 citations · 14 references

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Abstract

The repeat BCG stimulation of PBMC obtained from BCG vaccinated individuals shows enhanced immune activation with respect to increased anti-BCG titre, IFN-gamma and ADA activity without concomitant increase in CD4 and CD8 cells. This study provides some basic data in future experiments in animal models with respect to repeat BCG vaccination.

References

14

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

Alexander S. Pym, Priscille Brodin, Laleh Majlessi et al. · Nature Medicine · 2003 · 643 citations · Full text

, , +7

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin

Leander Grode · Journal of Clinical Investigation · 2005 · 550 citations · Full text

Enhanced Immunogenicity and Protective Efficacy Against <i>Mycobacterium tuberculosis</i> of Bacille Calmette-Guerin Vaccine Using Mucosal Administration and Boosting with a Recombinant Modified Vaccinia Virus Ankara

Nilu Goonetilleke, Helen McShane, Carolyn M. Hannan et al. · The Journal of Immunology · 2003 · 359 citations · Full text

Long-term Efficacy of BCG Vaccine in American Indians and Alaska Natives

Naomi Aronson, Mathuram Santosham, George W. Comstock et al. · JAMA · 2004 · 332 citations

Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi

J. M. Pönnighaus, E. Msosa, P.J.K. Gruer et al. · The Lancet · 1992 · 208 citations

, , +7