Aggressive systemic mastocytosis with sarcoma-like growth in the skeleton, leukemic progression, and partial loss of mast cell differentiation antigens

Abstract

Systemic mastocytosis (SM) is a clonal disease of mast cells (MC) and their progenitors.[1][1] The hallmark of the disease is the multifocal accumulation of MC in one or more extracutaneous organs. The clinical course and prognosis in SM vary among patients.[1][1],[2][2] Based on WHO criteria, 4