Platelet Serotonin Transporter in Patients With Diarrhea-Predominant Irritable Bowel Syndrome Both Before and After Treatment With Alosetron

Abstract

The present results indicate that SERT expressed on platelet membranes of D-IBS patients is characterized by low density and binding affinity and suggest a possible correlation between the reduced capacity of serotonin reuptake and the severity of D-IBS symptoms.