MICROANGIOPATHY IN KIDNEY AND SIMULTANEOUS PANCREAS/KIDNEY RECIPIENTS TREATED WITH TACROLIMUS: EVIDENCE OF ENDOTHELIN AND CYTOKINE INVOLVEMENT

Abstract

These data are consistent with a mechanism of microangiopathy involving endothelial cell injury (associated with tacrolimus treatment), and accompanied by cytokines (IL-10, IL-12, tumor necrosis factor-a, interferon-gamma) that affect expression of adhesion molecules, chemokines (IL-8) that direct the influx of white blood cells and endothelins that may exacerbate underlying hypertension and increase shear force-related red blood cell destruction.