Signal-Crosstalk Between Rho/ROCK and c-Jun NH <sub>2</sub> -Terminal Kinase Mediates Migration of Vascular Smooth Muscle Cells Stimulated by Angiotensin II - Concepedia

Concepedia

Publication | Open Access

Signal-Crosstalk Between Rho/ROCK and c-Jun NH <sub>2</sub> -Terminal Kinase Mediates Migration of Vascular Smooth Muscle Cells Stimulated by Angiotensin II

DOI Full Paper Access

115

Citations

43

References

2005

Year

Haruhiko Ohtsu, Mizuo Mifune, Gerald D. Frank, Shuichi Saito, Tadashi Inagami, Shokei Kim‐Mitsuyama, Yoh Takuwa, Terukatsu Sasaki, Jeffrey D. Rothstein, Hiroyuki Suzuki,

Arteriosclerosis Thrombosis and Vascular Biology

Abstract

PKCdelta/PYK2-dependent Rho/ROCK activation through PDZ-RhoGEF mediates Ang II-induced VSMC migration via JNK activation in VSMCs, providing a novel mechanistic role of the Rho/ROCK cascade that is involved in vascular remodeling.

References

	Year	Citations

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