Publication | Open Access
Synthesis and Anti-HIV-1 Activity of New Delavirdine Analogues Carrying Arylpyrrole Moieties.
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2001
Year
ImmunologyDelavirdine AnaloguesChemistryAntiviral DrugPharmaceutical ChemistryCompound 1AaMedicinal ChemistrySelective Anti-hiv-1 ActivityAntiviral Drug DevelopmentNeurovirologyVirologyHivPharmacologyAntiviral CompoundAnti-hiv-1 ActivityNatural SciencesAntiviral ResponseAntiviral TherapyMedicineSynthetic ChemistryDrug Discovery
In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.
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