A Reactive Oxygen Species (ROS)‐Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells

Abstract

Stimuli-responsive release: The high levels of reactive oxygen species (ROS) in prostate cancer cells can be exploited to trigger cancer-targeted gene delivery. A ROS-responsive thioketal-based cationic polymer was synthesized and functionalization with a cancer-targeting peptide led to selective and enhanced gene transfection in prostate cancer cells (see scheme).