Concepedia

Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with Formation of N-oxides — a chemical model for antimalarial mode of action

Richard K. Haynes, Hendry Hung‐On Pai, A. Voerste

Tetrahedron Letters · 1999 · 73 citations · 19 references

DOI

Concepts

References

19

Improved preparation of tertiary amine N-oxides

J. Cymerman Craig, K. K. Purushothaman · The Journal of Organic Chemistry · 1970 · 211 citations

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Unified Mechanistic Framework for the Fe(II)-Induced Cleavage of Qinghaosu and Derivatives/Analogues. The First Spin-Trapping Evidence for the Previously Postulated Secondary C-4 Radical

Wenmin Wu, Yikang Wu, Yu‐Lin Wu et al. · Journal of the American Chemical Society · 1998 · 175 citations

, , +15

Cytotoxic Terpenoids and Flavonoids from<i>Artemisia annua</i>

Guoqiang Zheng · Planta Medica · 1994 · 139 citations

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Characterization of the First Covalent Adduct between Artemisinin and a Heme Model

Anne Robert, Bernard Meunier · Journal of the American Chemical Society · 1997 · 127 citations

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Stereochemistry-Dependent Cytotoxicity of Some Artemisinin Derivatives

Aäron C. Beekman, Adriaan R. W. Barentsen, Herman J. Woerdenbag et al. · Journal of Natural Products · 1997 · 115 citations

, , +10