Lipase catalysed Michael addition of secondary amines to acrylonitrile

Oliver Torre, Ignacio Alfonso, Vicente Gotor

Chemical Communications · 2004 · 179 citations · 5 references

Concepts

Abstract

A new enzymatic process is described. Different preparations of lipase B from Candida antarctica are able to catalyse Michael-type addition of secondary amines to acrylonitrile. This new reaction widens the applicability of these biocatalysts in organic synthesis.

References

5