Asymmetric Hydrogenation of Quinolines and Isoquinolines Activated by Chloroformates

Abstract

Active ingredient: Optically active tetrahydroquinolines and tetrahydroisoquinolines can be obtained by the asymmetric hydrogenation of quinolines and isoquinolines with chloroformates as the activating reagent (e.g., ClCO2Bn, see scheme). The method has been applied to the asymmetric synthesis of several naturally occurring alkaloids. Bn=benzyl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503073_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.