Publication | Closed Access
Efficient Synthesis of 2‐Aminothiazoles and Fanetizole in Liquid PEG‐400 at Ambient Conditions
34
Citations
26
References
2009
Year
EngineeringOrganic ChemistryEfficient SynthesisChemistryPharmaceutical ChemistryDiversity Oriented SynthesisEthylene Glycol‐400Anti‐inflammatory DrugLiquid Peg‐400DerivativesAmbient ConditionsDiversity-oriented SynthesisPractical ProcedureSynthesis MethodPharmacologyEnantioselective SynthesisBiomolecular EngineeringNatural SciencesSynthetic Chemistry
Abstract A simple and practical procedure for the synthesis of 2‐aminothiazoles from α‐tosyloxyketones and thioureas is described using PEG‐400[poly(ethylene glycol‐400)] at ambient conditions. The developed protocol is successfully applied for the preparation of an anti‐inflammatory drug, Fanetizole.
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