Synthesis, Antitumor Activity, and Tolerability of Phospholipids Containing Nitrogen Homologues

Abstract

Replacing the N atom with an As or P atom in antineoplastically active phospholipids 1 and 2 (Z  N) leads to homologous compounds (Z  As, P) that are equally effective against tumors and have fewer side effects than the N-containing phospholipids. This marks definite progress in cancer treatment with chemotherapeutically active phospholipids.