Tumor 3′-Deoxy-3′-¹⁸F-Fluorothymidine (¹⁸F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of ¹⁸F-FLT PET Studies in Lung Tumors

Abstract

The absence of observable correlations of the imaging parameters with TK1 activity suggests that (18)F-FLT uptake and retention within cells may be complicated by a variety of still undetermined factors in addition to TK1 enzymatic activity.