Loperamide Toxicity in a Collie with the MDR1 Mutation Associated with Ivermectin Sensitivity

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene

Katrina L. Mealey, Steve A. Bentjen, John Gay et al. · Pharmacogenetics · 2001 · 452 citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Increased drug delivery to the brain by P-glycoprotein inhibition

Abu Sadeque · Clinical Pharmacology & Therapeutics · 2000 · 423 citations

Medicine, Pharmacokinetics, Pharmacology +13

Interaction of Morphine, Fentanyl, Sufentanil, Alfentanil, and Loperamide with the Efflux Drug Transporter P-glycoprotein

Christoph Wandel, Richard Kim, Margaret Wood et al. · Anesthesiology · 2002 · 215 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Abuse potential of loperamide

Jerome H. Jaffe, Maureen Kanzler · Clinical Pharmacology & Therapeutics · 1980 · 74 citations

Medicine, Pharmacology, Pharmacotherapy +14