In Vivo Imaging of Human Acetylcholinesterase Density in Peripheral Organs Using ¹¹C-Donepezil: Dosimetry, Biodistribution, and Kinetic Analyses

Abstract

(11)C-donepezil PET is suitable for imaging acetylcholinesterase densities in peripheral organs. Its uptake may potentially be quantitated with static whole-body PET scans not requiring arterial blood sampling. We also demonstrated high (11)C-donepezil binding in bacterial abscesses. We propose that (11)C-donepezil PET imaging may be able to quantify the parasympathetic innervation of organs but also detect nonneuronal cholinergic activity in infections.