Conjunctival Melanomas Harbor <i>BRAF</i> and <i>NRAS</i> Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas

Abstract

The presence of NRAS or BRAF mutations in a mutually exclusive pattern in roughly half (47%) of conjunctival melanomas and the pattern of CNAs argue for conjunctival melanoma being closely related to cutaneous and mucosal melanoma but entirely distinct from uveal melanoma. Patients with metastatic conjunctival melanoma should be considered for therapeutic modalities available for metastatic cutaneous and mucosal melanoma including clinical trials of novel agents.