Hydro‐ethanolic extract of cashew tree (<i>Anacardium occidentale</i>) nut and its principal compound, anacardic acid, stimulate glucose uptake in C2C12 muscle cells

Abstract

Activation of adenosine monophosphate-activated protein kinase by CSE and AA likely increases plasma membrane glucose transporters, resulting in elevated glucose uptake. In addition, the dysfunction of mitochondrial oxidative phosphorylation may enhance glycolysis and contribute to increased glucose uptake. These results collectively suggest that CSE may be a potential anti-diabetic nutraceutical.