γ-Selective Addition to 1,1-Difluoroallenes: Three-component Coupling Leading to 2,2-Disubstituted 1,1-Difluoroalkenes

Abstract

Abstract 1,1-Difluoroallenes underwent γ-selective addition with alkylcopper reagents. The resulting 2,2-difluorovinylcopper intermediates were captured by electrophiles or subjected to palladium-catalyzed coupling to give 2,2-disubstituted 1,1-difluoroalkenes in good yield.