Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Anne Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell · 1999 · 6.5K citations · Full text

Systems Biology, Signal Transduction, Cell Regulation +10

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science · 2004 · 3.4K citations

Engineering, Months470last 12, Data Science +15

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

B. Nave, D. Margriet Ouwens, Dominic J. Withers et al. · Biochemical Journal · 1999 · 918 citations · Full text

Convergence Point, Protein Translation, Insulin Signaling +17

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

Yardena Samuels, Luis A. Díaz, Oleg Schmidt‐Kittler et al. · Cancer Cell · 2005 · 909 citations · Full text

Oncology, Mutant Pik3ca, Cell Regulation +13

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

Sohye Kang, Andreas G. Bader, Peter K. Vogt · Proceedings of the National Academy of Sciences · 2005 · 821 citations · Full text

Phosphatidylinositol 3-Kinase Mutations, Tumor Biology, Signaling Pathway +16