The Enantioselective Allylation and Crotylation of Sterically Hindered and Functionalized Aryl Ketones: Convenient Access to Unusual Tertiary Carbinol Structures

Abstract

A strained allylsilane reagent is highly effective in the enantioselective allylation of hydroxyphenylketones. The method is uniquely tolerant both of sterically hindered aliphatic ketones and highly functionalized diaryl ketones and has been extended to include the first examples of highly diastereo- and enantioselective ketone crotylation, which provides access to both diastereomers. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600910_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.