Total Synthesis of the Proposed Azaspiracid‐1 Structure, Part 1: Construction of the Enantiomerically Pure C1–C20, C21–C27, and C28–C40 Fragments

Abstract

As a build-up to the synthesis of the proposed structure of azaspiracid, both enantiomers of fragments 2, 3, and 4 were synthesized stereoselectively. Piv=pivaloyl, PFP=pentafluorophenyl, Teoc=2-(trimethylsilyl)ethoxycarbonyl, TES=triethylsilyl.