Protein-based soft micro-optics fabricated by femtosecond laser direct writing

Abstract

In this work, we report a novel soft diffractive micro-optics, called ‘microscale kinoform phase-type lens (micro-KPL)’, which is fabricated by femtosecond laser direct writing (FsLDW) using bovine serum albumin (BSA) as building blocks and flexible polydimethylsiloxane (PDMS) slices as substrates. By carefully optimizing various process parameters of FsLDW (e.g., average laser power density, scanning step, exposure time on a single point and protein concentration), the as-formed protein micro-KPLs exhibit excellent surface quality, well-defined three-dimensional (3D) geometry and distinctive optical properties, even in relatively harsh operation environments (for instance, in strong acid or base). Laser shaping, imaging and other optical performances can be easily achieved. More importantly, micro-KPLs also have unique flexible and stretchable properties as well as good biocompatibility and biodegradability. Therefore, such protein hydrogel-based micro-optics may have great potential applications, such as in flexible and stretchable photonics and optics, soft integrated optical microsystems and bioimplantable devices. Scientists have used direct laser writing to fabricate flexible and biocompatible optical elements from a protein hydrogel. Yun-Lu Sun and co-workers from Jilin University in China and Pohang University of Science and Technology in Korea say that the miniature optical components produced using this approach could be useful for use in photonic implants or as stretchable optical devices. They fabricated soft, phase-type diffractive lenses with diameters of 50–100 µm by focusing femtosecond pulses from a Ti:sapphire laser into an aqueous ‘protein ink’ comprising a mixture of bovine serum albumin and the photosensitizer methylene blue. Irradiated regions underwent two-photon polymerization to form a soft protein hydrogel. By moving both the laser beam and the sample, the researchers successfully fabricated a three-dimensional optic featuring the desired series of concentric rings needed to act as a phase-type lens.