Expression pattern of synaptic vesicle protein 2 (<scp>SV</scp>2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis

Abstract

In classical MTS1A, the expression of SV2 isoforms is altered with a marked decrease of SV2A and SV2B paralleling synaptic loss and a selective increase of SV2C in sprouting mossy fibres. These findings suggest a different physiology of sprouting synapses and the possibility to target them with SV2C-specific strategies.