Rapid Analysis of Organic Compounds by Proton‐Detected Heteronuclear Correlation NMR Spectroscopy with 40 kHz Magic‐Angle Spinning

Abstract

High-sensitivity proton detection enabled acquisition of well-resolved two-dimensional spectra in only 30 minutes for less than 5 mg of organic compounds at natural abundance. Besides faster resonance assignment, rapid analysis of crystal polymorphism, molecular dynamics, and H-bonding is possible. This method is applicable to both pure and dosage forms of solid pharmaceuticals, such as ibuprofen (see picture).