Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

Abstract

Resequencing of TGR5 along with functional investigations of novel variants provided unique insight into an important candidate gene for several inflammatory and metabolic conditions. While significant TGR5 associations were detected in both UC and PSC, further studies are needed to conclusively define the role of TGR5 variation in these diseases.