Concepedia

Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease

Xiaotian Huang, Zhong‐Ming Qian, Xuan He, Qi Gong, Ka-Chun Wu, Lirong Jiang, Lina Lü, Zhou-Jing Zhu, Haiyan Zhang, Wing‐Ho Yung,

Neurobiology of Aging · 2013 · 89 citations · 28 references

DOI

Concepts

References

28

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

Mark A. Smith, Peggy L.R. Harris, Lawrence M. Sayre et al. · Proceedings of the National Academy of Sciences · 1997 · 1.4K citations

, , +17

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

James A. Duce, Andrew Tsatsanis, Michael A. Cater et al. · Cell · 2010 · 669 citations · Full text

, , +12

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei, Scott Ayton, David I. Finkelstein et al. · Nature Medicine · 2012 · 584 citations

, , +14

An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript

Jack T. Rogers, Jeffrey Randall, Catherine M. Cahill et al. · Journal of Biological Chemistry · 2002 · 546 citations · Full text

, , +14

Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease

Haiyan Zhang, Xi Tang · Trends in Pharmacological Sciences · 2006 · 173 citations

, , +16