Pro12Ala Polymorphism in the<i>PPARG</i>Gene Contributes to the Development of Diabetic Nephropathy in Chinese Type 2 Diabetic Patients

Abstract

Our results indicated that the Pro/Pro genotype and smoking were significant independent risk factors for diabetic nephropathy. The possible synergistic effects of genotype and smoking may aggravate oxidative stress and contribute to the development of diabetic nephropathy.