Synthesis of Conformationally Restricted 2,3-Diarylbenzo[<i>b</i>]furan by the Pd-Catalyzed Annulation of <i>o</i>-Alkynylphenols: Exploring a Combinatorial Approach

Abstract

The palladium/bpy-catalyzed annulation of o-alkynylphenol with various aryl halides to generate diversified 2,3-diarylbenzo[b]furan is herein described. This method provides an efficient synthetic pathway for the combinatorial synthesis of conformationally restricted 2,3-diarylbenzo[b]furan for drug discovery.