Clinical and Vaccine Immunology · 2004 · 241 citations · 13 references
Life SciencesGeneticsMolecular GeneticsImmunogeneticsImmunology Of Infectious DiseasesInnate ImmunityInnate Immune Gene PolymorphismsInnate Immune ReceptorsPattern Recognition ReceptorsReceptor PolymorphismsToll-like Receptor GeneticsToll-like ReceptorsImmune Response Gene Polymorphism AnalysisLung Immune ResponseToll-like Receptor 2 GeneticsToll-like Receptor Gene PolymorphismsToll-like Receptor-mediated Innate Immune ResponseToll-like Receptors In Bacterial Immunity
Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.
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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
Nancy C. Arbour, Eva Lorenz, Brian C. Schutte et al. · Nature Genetics · 2000 · 2K citations
Life Sciences, Genetics, Immunology +10