Coadministered Nitrous Oxide Enhances the Effect of Isoflurane on GABAergic Transmission by an Increase in Open-Channel Block

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

Erwin Neher, Joe Henry Steinbach · The Journal of Physiology · 1978 · 849 citations · Full text

Medicine, Pharmacology, Physiology +16

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

David Colquhoun, B. Sakmann · The Journal of Physiology · 1985 · 768 citations

Life Sciences, Pharmacology, Physiology +17

Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin

Vesna Jevtović‐Todorović, S. M. Todorovć, Steven Mennerick et al. · Nature Medicine · 1998 · 679 citations

Life Sciences, Neuroscience, Pharmacology +14

On the stochastic properties of single ion channels

David Colquhoun, Alan G. Hawkes · Proceedings of the Royal Society of London. Series B, Biological sciences · 1981 · 674 citations

Natural Sciences, Biophysics, Physics +17

Desensitized states prolong GABAA channel responses to brief agonist pulses

Mathew V. Jones, Gary L. Westbrook · Neuron · 1995 · 589 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14