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Nonclassical antifolates, part 4. 5-(2-Aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study

Medicinal ChemistryBioorganic ChemistryBiochemistryMedicineNatural SciencesRational Drug DesignPharmacological AgentNew ClassPharmacotherapyDhfr InhibitorsDrug DevelopmentPharmacologyPharmaceutical ChemistryInhibitory ActivityDrug DiscoveryNonclassical Antifolates