Organic Letters · 2012 · 25 citations · 45 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistrySynthetic Medicinal ChemistryAddition ReactionsHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisArylation ReactionsChemical Synthesis Of AnaloguesIsoquinoline ChemistryIsoquinoline SynthesisNucleophilic ReactivityOne-pot DeprotectionOne-pot Library SynthesisQuinoline Synthesis
A novel approach for the direct C-4 arylation of N-methyl-1,2,3,4-tetrahydroisoquinolines by nucleophilic addition of β-aminocarbanions to benzynes is described which provides a one-pot procedure for synthesis of the title compounds.
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