Concepedia

Scaffold and cell line based approaches for QSAR studies on anticancer agents

Shruti Satbhaiya, O.P. Chourasia

RSC Advances · 2015 · 11 citations · 42 references

DOI

Concepts

Abstract

Importance of 2D QSAR in drug discovery, lower number of descriptors containing models shows best statistical parameters, number of involved scaffolds in models affects the statistical values.

References

42

Beware of q2!

Alexander Golbraikh, Alexander Tropsha · Journal of Molecular Graphics and Modelling · 2002 · 3.7K citations

Estimating The Cost Of New Drug Development: Is It Really $802 Million?

Christopher Adams, Van V. Brantner · Health Affairs · 2006 · 910 citations

, , +10

Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents

B. P. Bandgar, Shrikant S. Gawande, Ragini G. Bodade et al. · Bioorganic & Medicinal Chemistry · 2009 · 312 citations

, , +11

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization

Mark Cushman, Dhanapalan Nagarathnam, Dhanushya Gopal et al. · Journal of Medicinal Chemistry · 1991 · 299 citations · Full text

, , +9

Synthesis, Biological Evaluation, and Quantitative Structure−Activity Relationship Analysis of New Schiff Bases of Hydroxysemicarbazide as Potential Antitumor Agents

Shijun Ren, Rubin Wang, Kenichi Komatsu et al. · Journal of Medicinal Chemistry · 2001 · 281 citations

, , +14