Combined Modifications of Mexiletine Pharmacophores for New Lead Blockers of Nav1.4 Channels

The crystal structure of a voltage-gated sodium channel

Jian Payandeh, Todd Scheuer, Ning Zheng et al. · Nature · 2011 · 1.4K citations

Natural Sciences, Biophysics, Crystal Structure +13

Molecular Determinants of State-Dependent Block of Na ⁺ Channels by Local Anesthetics

David S. Ragsdale, Jancy C. McPhee, Todd Scheuer et al. · Science · 1994 · 861 citations

Medicine, Neuroscience, Pharmacology +17

Lidocaine block of cardiac sodium channels.

Bruce P. Bean, Charles J. Cohen, Richard W. Tsien · The Journal of General Physiology · 1983 · 660 citations · Full text

Medicine, Pharmacology, Physiology +17

Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes

Petr Pávek, Lucie Stejskalová, Lucie Krausová et al. · Frontiers in Pharmacology · 2012 · 378 citations · Full text

Medicine, Molecular Biology, Pharmacology +14

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

Emily C. McCusker, Claire Bagnéris, C.E. Naylor et al. · Nature Communications · 2012 · 319 citations · Full text

Natural Sciences, Biology, Biophysics +17