Rifampicin Reduces Susceptibility to Ofloxacin in Rifampicin-resistant <i>Mycobacterium tuberculosis</i> through Efflux

Abstract

Exposure of rifampicin resistant M. tuberculosis strains to rifampicin can potentially compromise the efficacy of the second-line treatment regimens containing ofloxacin, thereby emphasising the need for rapid diagnostics to guide treatment. Efflux pump inhibitors have the potential to improve the efficacy of anti-tuberculosis drug treatment.