Concepedia

P-Glycoprotein Limits the Brain Penetration of Nonsedating but not Sedating H1-Antagonists

Cuiping Chen, Elizabeth Hanson, J. W. Watson, Jae Sung Lee

Drug Metabolism and Disposition · 2003 · 224 citations · 23 references

DOI

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23

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

, , +14

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar et al. · Proceedings of the National Academy of Sciences · 1997 · 941 citations

, , +11

Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery

Joseph W. Polli, Stephen A. Wring, Joan E. Humphreys et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 662 citations

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The multidrug resistance protein family

Piet Borst, Raymond Evers, Marcel Kool et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1999 · 650 citations

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OATP and P-Glycoprotein Transporters Mediate the Cellular Uptake and Excretion of Fexofenadine

Mirjana Cvetković, Brenda F. Leake, Martin F. Fromm et al. · Drug Metabolism and Disposition · 1999 · 595 citations

, , +17