Loss of K‐Cl co‐transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold

The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

Claudio Rivera, Juha Voipio, John A. Payne et al. · Nature · 1999 · 2.1K citations

Life Sciences, Neurobiology, Neuroscience +14

Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na–Cl cotransporter

David B. Simon, Carol Nelson‐Williams, Margaret J. Bia et al. · Nature Genetics · 1996 · 1.2K citations

Life Sciences, Genetics, Human Genetics +2

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na–K–2CI cotransporter NKCC2

David B. Simon, Fiona E. Karet, Jahed M. Hamdan et al. · Nature Genetics · 1996 · 907 citations

Medicine, Nephrology, Calcium Homeostasis +6

KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness

Christian Kubisch, Björn C. Schroeder, Thomas Friedrich et al. · Cell · 1999 · 868 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Disruption of KCC2 Reveals an Essential Role of K-Cl Cotransport Already in Early Synaptic Inhibition

Christian A. Hübner, Valentin Stein, Irm Hermans‐Borgmeyer et al. · Neuron · 2001 · 607 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17