Complete Regio‐ and Stereoselective Construction of Highly Substituted Silyl Enol Ethers by Three‐Component Coupling

Abstract

Three components for total control: Trisubstituted silyl enol ethers were prepared by three-component coupling of α-silyl α,β-unsaturated ketones, organocopper reagents, and organic halides with complete regio- and stereoselectivity (see scheme). The reaction proceeded through a 1,3 migration of the silyl group via cyclic silicate intermediates, which controlled the configuration of the silyl enol ethers.