Concepedia

Elevated CSF prostaglandin E <sub>2</sub> levels in patients with probable AD

Thomas J. Montine, Kathrin R. Sidell, Brenda C. Crews, William R. Markesbery, Lawrence J. Marnett, L. Jackson Roberts, Jason D. Morrow

Neurology · 1999 · 280 citations · 20 references

DOI

Abstract

These data suggest that cyclo-oxygenase activity may not contribute significantly to CNS oxidative damage in AD. Increased CSF PGE2 concentration in probable AD patients suggest that cyclo-oxygenase inhibitors may benefit AD patients by limiting PG production.

References

20

Clinical diagnosis of Alzheimer's disease

Guy M. McKhann, David A. Drachman, Marshall Folstein et al. · Neurology · 1984 · 27.8K citations · Full text

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

Suzanne S. Mirra, Albert Heyman, Daniel W. McKeel et al. · Neurology · 1991 · 5K citations

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

Giulio Maria Pasinetti, Paul Aisen · Neuroscience · 1998 · 461 citations

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Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

Lisa M. Landino, Brenda C. Crews, Michael D. Timmons et al. · Proceedings of the National Academy of Sciences · 1996 · 425 citations · Full text

, , +17

Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

Raymond N. DuBois, Joseph Awad, Jason D. Morrow et al. · Journal of Clinical Investigation · 1994 · 373 citations · Full text

, , +19